UK:*UK and possibly other pronunciationsUK and possibly other pronunciations/ˈɪsəs/US:USA pronunciation: respellingUSA pronunciation: respelling(isəs)

WordReference Random House Unabridged Dictionary of American English © 2020
Is•sus  (isəs),USA pronunciation n. 
  1. Ancient History, Place Namesan ancient town in Asia Minor, in Cilicia: victory of Alexander the Great over Darius III 333 b.c.

Collins Concise English Dictionary © HarperCollins Publishers::
Issus /ˈɪsəs/ n
  1. an ancient town in S Asia Minor, in Cilicia north of present-day Iskenderun: scene of a battle (333 bc) in which Alexander the Great defeated the Persians

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